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Total: 6532
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Central Nervous System Neoplasms; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Glioblastoma; Glioma; Neuroblastoma; Rectal Neoplasms; Adenocarcinoma, Follicular; Astrocytoma; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Colorectal Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Gliosarcoma; Head and Neck Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Mesothelioma; Multiple Myeloma; Neoplasm Metastasis; Oligodendroglioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Stomach Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Medullary; Neoplasms; Thyroid Neoplasms
Ephrin receptor inhibitor
Small molecule
Approved
Unknown
Unknown
Asthma; Heart Failure; Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive
Unknown
Small molecule
Approved
DERMATOLOGY; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Kidney Diseases; Alcoholism; Diabetic Neuropathies; Migraine Disorders; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome
Voltage-gated calcium channel modulator
Small molecule
Approved
CANCER; OTHER; RESPIRATORY
ORAL
Breast Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Glioblastoma; Kidney Diseases; Lung Neoplasms; Prostatic Neoplasms, Castration-Resistant; Adenocarcinoma; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Endometrial Neoplasms; Granuloma, Plasma Cell; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Multiple Myeloma; Neurofibromatosis 2; Stomach Neoplasms; Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; Lymphoma, Large B-Cell, Diffuse; Neoplasms
ALK tyrosine kinase receptor inhibitor
Small molecule
Approved
IMMUNE SYSTEM
ORAL
Thrombocytopenia; Hepatitis C; Hepatitis C, Chronic; Virus Diseases
Hepatitis C virus serine protease, NS3/NS4A inhibitor
Small molecule
Approved
Unknown
Unknown
Otitis Media with Effusion; Alcohol Drinking; Anxiety; Arthritis, Rheumatoid; Celiac Disease; Gingivitis; Acne Vulgaris; Amyotrophic Lateral Sclerosis; Burns; Chemical and Drug Induced Liver Injury; Hidradenitis Suppurativa; Ileus; Intervertebral Disc Degeneration; Severe Acute Respiratory Syndrome; Tinea Pedis; Cardiovascular Diseases; Dental Caries; Hemorrhoids; Pain; Periodontitis; Tension-Type Headache; Tooth Diseases; Multiple Sclerosis; Short Bowel Syndrome
Unknown
Small molecule
Approved
OTHER
ORAL
Hepatitis C; Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Small molecule
Unknown
Unknown
Unknown
Neoplasms; Depressive Disorder, Major; Lymphoma; Nervous System Diseases; Obesity; Schizophrenia; Cognitive Dysfunction; Dementia; Dermatitis; Dermatitis, Atopic; Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Respiratory Distress Syndrome; Asthma; Bronchiectasis; Diabetic Nephropathies; Psoriasis; Bronchitis, Chronic; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
Phosphodiesterase 4 inhibitor
Small molecule
Approved
CARDIOVASCULAR; HEMATOLOGY; OTHER
ORAL
Obesity, Morbid; Renal Insufficiency, Chronic; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Antiphospholipid Syndrome; Coronary Disease; Diabetes Mellitus, Type 2; Hematoma; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Peripheral Arterial Disease; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Stroke; Thrombocytopenia; Venous Thromboembolism; Atrial Fibrillation; Pulmonary Embolism; Thrombosis; Venous Thrombosis
Coagulation factor X inhibitor
Small molecule
Approved
Unknown
Unknown
Marijuana Abuse; Memory Disorders; Anxiety Disorders; Depressive Disorder, Major; Depressive Disorder
Unknown
Small molecule
Approved
OTHER
INTRAVENOUS
Arthritis, Rheumatoid; Heart Failure
Diagnostic agent
Small molecule
Approved
CARDIOVASCULAR; OTHER
ORAL
Hypertension; Stroke
Type-1 angiotensin II receptor antagonist
Small molecule
Approved
Unknown
Unknown
Osteoarthritis
Unknown
Small molecule
Approved
GASTROINTESTINAL
ORAL
Clostridium Infections; Diarrhea; Infections
DNA-directed RNA polymerase inhibitor
Small molecule
Approved
GASTROINTESTINAL; OTHER; UROLOGY AND KIDNEY
ORAL
Biliary Tract Neoplasms; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Bile Duct Neoplasms; Carcinoma; Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Glioblastoma; Hemangiosarcoma; Liposarcoma; Macular Degeneration; Melanoma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neoplasms
Discoidin domain-containing receptor 2 inhibitor
Small molecule
Approved
RESPIRATORY
ORAL
Sinusitis; Liver Diseases; Bronchitis, Chronic; Kartagener Syndrome; Pulmonary Disease, Chronic Obstructive; Cystic Fibrosis; Respiratory Tract Diseases
Cystic fibrosis transmembrane conductance regulator positive modulator
Small molecule
Approved
CANCER; OTHER; UROLOGY AND KIDNEY
ORAL
Blast Crisis; Breast Neoplasms; Carcinoma; Endometriosis; Gliosarcoma; Mesothelioma; Stomach Neoplasms; Adrenal Cortex Neoplasms; Biliary Tract Neoplasms; Carcinoid Tumor; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Sarcoma, Alveolar Soft Part; Skin Neoplasms; Solitary Fibrous Tumors; Thyroid Neoplasms; Carcinoma, Pancreatic Ductal; Kidney Neoplasms; Carcinoma, Renal Cell; Neoplasms
Vascular endothelial growth factor receptor inhibitor
Small molecule
Unknown
Unknown
Unknown
Ischemic Stroke; Liver Cirrhosis; Nephrotic Syndrome; Thromboembolism; Foramen Ovale, Patent; Heart Failure; Hemorrhage; Renal Insufficiency, Chronic; Takotsubo Cardiomyopathy; Acute Coronary Syndrome; Anemia, Sickle Cell; Aortic Valve Stenosis; Atrial Flutter; Hematoma; Ischemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Severe Acute Respiratory Syndrome; Venous Thromboembolism; Atrial Fibrillation; Embolism; Pulmonary Embolism; Stroke; Thrombosis; Venous Thrombosis
Coagulation factor X inhibitor
Small molecule
Approved
GASTROINTESTINAL
ORAL
Breast Neoplasms; Irritable Bowel Syndrome; Acquired Immunodeficiency Syndrome; Diarrhea
Anoctamin-1 blocker
Small molecule
Approved
Unknown
Unknown
Alzheimer Disease; Cognitive Dysfunction
Diagnostic agent
Small molecule
Approved
Unknown
Unknown
Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute; Liver Diseases; Multiple Myeloma; Urogenital Neoplasms; Adenocarcinoma, Follicular; Adrenal Cortex Neoplasms; Astrocytoma; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Neuroendocrine; Cholangiocarcinoma; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Melanoma; Neuroendocrine Tumors; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Thyroid Neoplasms; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Liver Diseases; Leprosy; Mycobacterium avium-intracellulare Infection; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tuberculosis
Unknown
Small molecule
Approved
CANCER
ORAL
Prostatic Neoplasms, Castration-Resistant; Glioblastoma; Multiple Myeloma; Primary Myelofibrosis; Prostatic Neoplasms; Basal Cell Nevus Syndrome; Breast Neoplasms; Carcinoma, Pancreatic Ductal; Glioma; Gliosarcoma; Graft vs Host Disease; Idiopathic Pulmonary Fibrosis; Leukemia, Myeloid, Acute; Medulloblastoma; Meningioma; Ovarian Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Carcinoma, Basal Cell; Neoplasms
Smoothened homolog inhibitor
Small molecule
Approved
OTHER
ORAL
Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 integrase inhibitor
Small molecule
Approved
CARDIOVASCULAR
ORAL
Adenoma; Alzheimer Disease; Colonic Neoplasms; Non-alcoholic Fatty Liver Disease; Cardiovascular Diseases; Severe Acute Respiratory Syndrome; Hypertriglyceridemia; Pancreatitis
Unknown
Small molecule
Approved
RESPIRATORY
ORAL
Tuberculosis
ATP synthase inhibitor
Small molecule
Approved
MUSCULOSKELETAL; OTHER
ORAL
Celiac Disease; Kidney Diseases; Paraparesis, Tropical Spastic; Immune System Diseases; Multiple Sclerosis
Dihydroorotate dehydrogenase inhibitor
Small molecule
Approved
OTHER
ORAL
Carcinoma, Non-Small-Cell Lung; Insulin Resistance; Malaria; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Acquired Immunodeficiency Syndrome; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; HIV Infections; Infections
Cytochrome P450 3A inhibitor
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Myelodysplastic Syndromes; Adenocarcinoma of Lung; Blast Crisis; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Stromal Tumors; Glioblastoma; Leukemia; Leukemia, Myeloid, Acute; Small Cell Lung Carcinoma; Thyroid Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Cardiovascular Diseases; Kidney Diseases; Liver Diseases; Marijuana Abuse; Substance-Related Disorders; Cocaine-Related Disorders; Opioid-Related Disorders; Peripheral Nervous System Diseases; Tobacco Use Disorder; Obesity
Unknown
Small molecule
Approved
CANCER
ORAL
Carcinoma, Renal Cell; Kidney Diseases; Liver Diseases; Pancreatic Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Lymphoma, Mantle-Cell; Ovarian Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Breast Neoplasms; Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant
Androgen Receptor antagonist
Small molecule
Approved
Unknown
Unknown
Pulmonary Disease, Chronic Obstructive
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown