DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 1496


Small molecule Approved OTHER INJECTION Unknown Diagnostic agent


Small molecule Approved IMMUNE SYSTEM; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Alopecia; Child Development Disorders, Pervasive; Premature Birth; Psychotic Disorders; Abortion, Spontaneous; Anemia, Sickle Cell; Breast Neoplasms; Hyperemesis Gravidarum; Intervertebral Disc Displacement; Low Back Pain; Marijuana Abuse; Mucositis; Multiple Sclerosis; Neoplasms; Opioid-Related Disorders; Paget Disease, Extramammary; Postoperative Complications; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Substance-Related Disorders; Substance Withdrawal Syndrome; Tinnitus; Tobacco Use Disorder; Urinary Bladder Neoplasms; Wounds and Injuries; Alcohol Drinking; Alcoholism; Anxiety; Azoospermia; Carpal Tunnel Syndrome; Chronic Pain; Delirium; Dementia; Depressive Disorder; Diabetic Neuropathies; Dyspepsia; Epilepsies, Partial; Fibromyalgia; Head and Neck Neoplasms; Herpes Zoster; Hot Flashes; Intervertebral Disc Degeneration; Liver Cirrhosis; Neuralgia; Oropharyngeal Neoplasms; Pain; Pelvic Organ Prolapse; Postoperative Nausea and Vomiting; Pruritus; Schizophrenia; Scoliosis; Sleep Initiation and Maintenance Disorders; Tremor; Vomiting; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome; Seizures Voltage-gated calcium channel modulator

Small molecule

Approved

IMMUNE SYSTEM; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS

ORAL

Alopecia; Child Development Disorders, Pervasive; Premature Birth; Psychotic Disorders; Abortion, Spontaneous; Anemia, Sickle Cell; Breast Neoplasms; Hyperemesis Gravidarum; Intervertebral Disc Displacement; Low Back Pain; Marijuana Abuse; Mucositis; Multiple Sclerosis; Neoplasms; Opioid-Related Disorders; Paget Disease, Extramammary; Postoperative Complications; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Substance-Related Disorders; Substance Withdrawal Syndrome; Tinnitus; Tobacco Use Disorder; Urinary Bladder Neoplasms; Wounds and Injuries; Alcohol Drinking; Alcoholism; Anxiety; Azoospermia; Carpal Tunnel Syndrome; Chronic Pain; Delirium; Dementia; Depressive Disorder; Diabetic Neuropathies; Dyspepsia; Epilepsies, Partial; Fibromyalgia; Head and Neck Neoplasms; Herpes Zoster; Hot Flashes; Intervertebral Disc Degeneration; Liver Cirrhosis; Neuralgia; Oropharyngeal Neoplasms; Pain; Pelvic Organ Prolapse; Postoperative Nausea and Vomiting; Pruritus; Schizophrenia; Scoliosis; Sleep Initiation and Maintenance Disorders; Tremor; Vomiting; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome; Seizures

Voltage-gated calcium channel modulator


Unknown Approved OTHER INJECTION Breast Neoplasms; Pancreatitis; Hemorrhage Plasma kallikrein inhibitor


Small molecule Approved OTHER TOPICAL Carcinoma, Squamous Cell; Keratosis, Actinic; Scleroderma, Localized; Vitiligo; Acne Vulgaris; Dermatitis, Atopic; Eczema; Radiodermatitis; Skin Diseases; Psoriasis Vitamin D receptor agonist


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemias; Hyperlipoproteinemia Type III; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism Peroxisome proliferator-activated receptor alpha agonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemias; Hyperlipoproteinemia Type III; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism

Peroxisome proliferator-activated receptor alpha agonist


Small molecule Approved OTHER ORAL Bipolar Disorder; Anemia; Epilepsy; Seizures Glutamate [NMDA] receptor antagonist


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER; PEDIATRICS ORAL Acidosis, Lactic; Acquired Immunodeficiency Syndrome; AIDS-Associated Nephropathy; AIDS Dementia Complex; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 reverse transcriptase inhibitor


Enzyme Approved OTHER UNKNOWN Granuloma, Lethal Midline; Leukemia; Leukemia, Biphenotypic, Acute; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma Asparagine hydrolytic enzyme


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL HIV Infections; Lecithin Cholesterol Acyltransferase Deficiency; Mental Disorders; Alcoholism; Cocaine-Related Disorders; Cognitive Dysfunction; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuralgia, Postherpetic; Neurofibromatosis 1; Opioid-Related Disorders; Substance-Related Disorders; Anxiety; Dementia; Epilepsy, Absence; Feeding and Eating Disorders; Mood Disorders; Obesity; Pain; Peripheral Nervous System Diseases; Schizophrenia; Bipolar Disorder; Depressive Disorder; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Seizures Sodium channel alpha subunit blocker

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

HIV Infections; Lecithin Cholesterol Acyltransferase Deficiency; Mental Disorders; Alcoholism; Cocaine-Related Disorders; Cognitive Dysfunction; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Neuralgia, Postherpetic; Neurofibromatosis 1; Opioid-Related Disorders; Substance-Related Disorders; Anxiety; Dementia; Epilepsy, Absence; Feeding and Eating Disorders; Mood Disorders; Obesity; Pain; Peripheral Nervous System Diseases; Schizophrenia; Bipolar Disorder; Depressive Disorder; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Seizures

Sodium channel alpha subunit blocker


Enzyme Approved OTHER INJECTION Anemia; Gaucher Disease; Thrombocytopenia Glucocerebroside hydrolytic enzyme


Enzyme Approved OTHER UNKNOWN Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Myeloproliferative Disorders; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma, Myeloid; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma Asparagine hydrolytic enzyme

Enzyme

Approved

OTHER

UNKNOWN

Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Myeloproliferative Disorders; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma, Myeloid; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Asparagine hydrolytic enzyme


Small molecule Approved DERMATOLOGY; DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY INJECTION; ORAL; TOPICAL Neoplasms, Neuroepithelial; Alopecia; Aspergillosis; beta-Thalassemia; Blast Crisis; DiGeorge Syndrome; Hematologic Diseases; Hypercholesterolemia; Kidney Tubular Necrosis, Acute; Leukemia, Plasma Cell; Lymphedema; Lymphoma, T-Cell; Paget Disease, Extramammary; Peripheral Nerve Injuries; Respiratory Syncytial Virus Infections; Scleroderma, Localized; Vasculitis; Venous Thromboembolism; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Sickle Cell; Asthma; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Colitis; Crohn Disease; Diabetes Mellitus; Edema; Encephalomyelitis; Epidermolysis Bullosa; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Granuloma, Lethal Midline; Hematologic Neoplasms; Hemoglobinuria, Paroxysmal; Hepatitis, Autoimmune; Hepatitis C; Hepatitis C, Chronic; Histiocytosis, Langerhans-Cell; Hypertension, Pulmonary; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Lichen Planus, Oral; Liver Diseases; Liver Failure; Lung Diseases; Lupus Erythematosus, Cutaneous; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Multiple Myeloma; Multiple Sclerosis; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasms; Nephrosis, Lipoid; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Purpura, Thrombocytopenic, Idiopathic; Sarcoma; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Thalassemia; Vulvar Lichen Sclerosus; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome; Wounds and Injuries; Arthritis, Rheumatoid; Bronchiolitis Obliterans; Carcinoma, Hepatocellular; Colitis, Ulcerative; Conjunctivitis, Allergic; Dermatitis, Atopic; Dermatitis, Seborrheic; Diabetes Mellitus, Type 1; Glomerulonephritis, Membranous; Graft vs Host Disease; Heart Diseases; Hodgkin Disease; Infertility; Keratoconjunctivitis; Kidney Diseases; Lupus Nephritis; Lymphoma, Non-Hodgkin; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Psoriasis; Renal Insufficiency; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Skin Neoplasms; Vitiligo; Eczema; Immune System Diseases FK506-binding protein 1A inhibitor

Small molecule

Approved

DERMATOLOGY; DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY

INJECTION; ORAL; TOPICAL

Neoplasms, Neuroepithelial; Alopecia; Aspergillosis; beta-Thalassemia; Blast Crisis; DiGeorge Syndrome; Hematologic Diseases; Hypercholesterolemia; Kidney Tubular Necrosis, Acute; Leukemia, Plasma Cell; Lymphedema; Lymphoma, T-Cell; Paget Disease, Extramammary; Peripheral Nerve Injuries; Respiratory Syncytial Virus Infections; Scleroderma, Localized; Vasculitis; Venous Thromboembolism; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Sickle Cell; Asthma; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Colitis; Crohn Disease; Diabetes Mellitus; Edema; Encephalomyelitis; Epidermolysis Bullosa; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Granuloma, Lethal Midline; Hematologic Neoplasms; Hemoglobinuria, Paroxysmal; Hepatitis, Autoimmune; Hepatitis C; Hepatitis C, Chronic; Histiocytosis, Langerhans-Cell; Hypertension, Pulmonary; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Lichen Planus, Oral; Liver Diseases; Liver Failure; Lung Diseases; Lupus Erythematosus, Cutaneous; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Multiple Myeloma; Multiple Sclerosis; Mycosis Fungoides; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neoplasms; Nephrosis, Lipoid; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Purpura, Thrombocytopenic, Idiopathic; Sarcoma; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Thalassemia; Vulvar Lichen Sclerosus; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome; Wounds and Injuries; Arthritis, Rheumatoid; Bronchiolitis Obliterans; Carcinoma, Hepatocellular; Colitis, Ulcerative; Conjunctivitis, Allergic; Dermatitis, Atopic; Dermatitis, Seborrheic; Diabetes Mellitus, Type 1; Glomerulonephritis, Membranous; Graft vs Host Disease; Heart Diseases; Hodgkin Disease; Infertility; Keratoconjunctivitis; Kidney Diseases; Lupus Nephritis; Lymphoma, Non-Hodgkin; Myasthenia Gravis; Myelodysplastic Syndromes; Nephrotic Syndrome; Psoriasis; Renal Insufficiency; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Skin Neoplasms; Vitiligo; Eczema; Immune System Diseases

FK506-binding protein 1A inhibitor


Small molecule Approved OTHER ORAL Panic Disorder; Severe Acute Respiratory Syndrome; Obsessive-Compulsive Disorder Serotonin transporter inhibitor


Small molecule Approved OTHER OPHTHALMIC Dry Eye Syndromes; Eye Diseases Glucocorticoid receptor agonist


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Herpes Simplex; Meniere Disease; Autoimmune Diseases; Eye Infections; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases Human herpesvirus 1 DNA polymerase inhibitor


Small molecule Approved GASTROINTESTINAL; OTHER; RESPIRATORY INHALATION; NASAL; ORAL; RECTAL Cholangitis, Sclerosing; Snoring; Aspergillosis, Allergic Bronchopulmonary; Breast Neoplasms; Bronchiolitis Obliterans; Diarrhea; Esophageal Stenosis; Glomerulonephritis, IGA; Hepatitis, Autoimmune; Hypersensitivity; Lung Neoplasms; Malnutrition; Melanoma; Nasal Polyps; Radiation Pneumonitis; Respiratory Distress Syndrome; Status Asthmaticus; Altitude Sickness; Bronchopulmonary Dysplasia; Colitis, Collagenous; Colitis, Lymphocytic; Colitis, Microscopic; Eosinophilic Esophagitis; Graft vs Host Disease; Liver Cirrhosis, Biliary; Proctitis; Proctocolitis; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Bronchitis, Chronic; Colitis, Ulcerative; Crohn Disease; Emphysema; Lung Diseases, Obstructive; Nasal Obstruction; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal Glucocorticoid receptor agonist

Small molecule

Approved

GASTROINTESTINAL; OTHER; RESPIRATORY

INHALATION; NASAL; ORAL; RECTAL

Cholangitis, Sclerosing; Snoring; Aspergillosis, Allergic Bronchopulmonary; Breast Neoplasms; Bronchiolitis Obliterans; Diarrhea; Esophageal Stenosis; Glomerulonephritis, IGA; Hepatitis, Autoimmune; Hypersensitivity; Lung Neoplasms; Malnutrition; Melanoma; Nasal Polyps; Radiation Pneumonitis; Respiratory Distress Syndrome; Status Asthmaticus; Altitude Sickness; Bronchopulmonary Dysplasia; Colitis, Collagenous; Colitis, Lymphocytic; Colitis, Microscopic; Eosinophilic Esophagitis; Graft vs Host Disease; Liver Cirrhosis, Biliary; Proctitis; Proctocolitis; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Bronchitis, Chronic; Colitis, Ulcerative; Crohn Disease; Emphysema; Lung Diseases, Obstructive; Nasal Obstruction; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

Glucocorticoid receptor agonist


Small molecule Approved OTHER ORAL Cardiovascular Diseases; Hypertension Voltage-gated L-type calcium channel blocker


Small molecule Approved OTHER ORAL Fallopian Tube Neoplasms; Gynecomastia; Ovarian Neoplasms; Peritoneal Neoplasms; Puberty, Precocious; Salivary Gland Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Severe Acute Respiratory Syndrome; Carcinoma; Neoplasms Androgen Receptor antagonist


Small molecule Approved CARDIOVASCULAR; IMMUNE SYSTEM; OTHER ORAL Neoplasms, Neuroepithelial; Arthritis, Rheumatoid; beta-Thalassemia; Carcinoma, Renal Cell; DiGeorge Syndrome; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Lymphoma, T-Cell; Pancreatic Neoplasms; Scleroderma, Diffuse; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Sickle Cell; Autoimmune Diseases; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; Hematologic Diseases; Hematologic Neoplasms; Hemoglobinuria, Paroxysmal; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; HIV Infections; Hyperlipoproteinemia Type I; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Liver Diseases; Lymphoma; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Purpura, Schoenlein-Henoch; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis, Pulmonary; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Small molecule

Approved

CARDIOVASCULAR; IMMUNE SYSTEM; OTHER

ORAL

Neoplasms, Neuroepithelial; Arthritis, Rheumatoid; beta-Thalassemia; Carcinoma, Renal Cell; DiGeorge Syndrome; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Lymphoma, T-Cell; Pancreatic Neoplasms; Scleroderma, Diffuse; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Sickle Cell; Autoimmune Diseases; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; Hematologic Diseases; Hematologic Neoplasms; Hemoglobinuria, Paroxysmal; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; HIV Infections; Hyperlipoproteinemia Type I; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Liver Diseases; Lymphoma; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Purpura, Schoenlein-Henoch; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis, Pulmonary; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Hypotension, Orthostatic; Nesidioblastosis; Obesity; Aging; Non-alcoholic Fatty Liver Disease; Atherosclerosis; Coronary Disease; Diabetes, Gestational; Hypercholesterolemia; Hypertension; Metabolic Diseases; Metabolic Syndrome; Diabetes Mellitus; Diabetes Mellitus, Type 2 Maltase-glucoamylase inhibitor


Small molecule Approved DERMATOLOGY; OTHER TOPICAL Dermatitis, Perioral; Dermatitis, Seborrheic; Acne Vulgaris; Erythema; Rosacea Unknown


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; IMMUNE SYSTEM; OTHER ORAL Alzheimer Disease; Lymphoma; Lymphoma, Non-Hodgkin; Paraparesis, Tropical Spastic; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Acquired Immunodeficiency Syndrome; AIDS-Associated Nephropathy; Carcinoma, Hepatocellular; Diarrhea; Liver Cirrhosis; Tuberculosis; Autoimmune Diseases; Hepatitis; Hepatitis B; Hepatitis B, Chronic; HIV Infections; Infections; Inflammation; Virus Diseases DNA inhibitor

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; IMMUNE SYSTEM; OTHER

ORAL

Alzheimer Disease; Lymphoma; Lymphoma, Non-Hodgkin; Paraparesis, Tropical Spastic; Sarcoma, Kaposi; Small Cell Lung Carcinoma; Acquired Immunodeficiency Syndrome; AIDS-Associated Nephropathy; Carcinoma, Hepatocellular; Diarrhea; Liver Cirrhosis; Tuberculosis; Autoimmune Diseases; Hepatitis; Hepatitis B; Hepatitis B, Chronic; HIV Infections; Infections; Inflammation; Virus Diseases

DNA inhibitor


Small molecule Approved GASTROINTESTINAL; OTHER INTRAVENOUS; ORAL Cystic Fibrosis; Laryngopharyngeal Reflux; Neoplasms; Pain; Endometrial Neoplasms; Eosinophilic Esophagitis; Leukemia, Lymphocytic, Chronic, B-Cell; Premature Birth; Pseudomyxoma Peritonei; Rectal Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Diabetes Mellitus, Type 1; Duodenal Ulcer; Esophagitis, Peptic; Gastritis; Gout; Helicobacter Infections; Idiopathic Pulmonary Fibrosis; Lymphoma; Osteoarthritis; Gastroesophageal Reflux; Peptic Ulcer; Stomach Ulcer Potassium-transporting ATPase inhibitor

Small molecule

Approved

GASTROINTESTINAL; OTHER

INTRAVENOUS; ORAL

Cystic Fibrosis; Laryngopharyngeal Reflux; Neoplasms; Pain; Endometrial Neoplasms; Eosinophilic Esophagitis; Leukemia, Lymphocytic, Chronic, B-Cell; Premature Birth; Pseudomyxoma Peritonei; Rectal Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Diabetes Mellitus, Type 1; Duodenal Ulcer; Esophagitis, Peptic; Gastritis; Gout; Helicobacter Infections; Idiopathic Pulmonary Fibrosis; Lymphoma; Osteoarthritis; Gastroesophageal Reflux; Peptic Ulcer; Stomach Ulcer

Potassium-transporting ATPase inhibitor


Small molecule Approved OTHER INJECTION Unknown Diagnostic agent


Small molecule Approved OTHER INJECTION Unknown Diagnostic agent

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Breast Neoplasms; Stress Disorders, Post-Traumatic; Alzheimer Disease; Bipolar Disorder; Cerebellar Ataxia; Child Development Disorders, Pervasive; Depressive Disorder; Depressive Disorder, Major; Melanoma; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Muscular Atrophy, Spinal; Obsessive-Compulsive Disorder; Peripheral Nervous System Diseases; Spinal Cord Injuries; Huntington Disease; Multiple System Atrophy; Spinal Cord Diseases; Spinocerebellar Ataxias; Supranuclear Palsy, Progressive; Amyotrophic Lateral Sclerosis

Sodium channel alpha subunit blocker

Small molecule

Approved

OTHER

ORAL

Glioblastoma; Vascular Diseases; Breast Neoplasms; Cocaine-Related Disorders; Epilepsy; Esophageal and Gastric Varices; Hypertension, Pulmonary; Hypoglycemia; Kidney Diseases; Lymphoma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Stress Disorders, Post-Traumatic; Tobacco Use Disorder; Atherosclerosis; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Portal; Hypertrophy, Left Ventricular; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Multiple Myeloma; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left

Adrenergic receptor alpha-1 antagonist


Small molecule Approved CARDIOVASCULAR; OTHER INJECTION Unknown HERG blocker

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER

INJECTION

Chordoma; Fanconi Anemia; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Retinoblastoma; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Hepatoblastoma; Lung Neoplasms; Multiple Myeloma; Nasopharyngeal Neoplasms; Peripheral Nervous System Diseases; Trigeminal Neuralgia; Head and Neck Neoplasms; Ovarian Neoplasms; Xerostomia

Reactive metabolite scavenging agent


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Atherosclerosis; Coronary Disease; Hypercholesterolemia; Hypertension; Diabetes Mellitus; Diabetes Mellitus, Type 2 Sulfonylurea receptor 1, Kir6.2 blocker

Small molecule

Approved

CANCER; OTHER

ORAL

Hypertension; Aging; Endometrial Neoplasms; Kallmann Syndrome; Anovulation; Breast Neoplasms, Male; Carcinoma; Endometriosis; Fibrous Dysplasia, Polyostotic; Hypertension, Pulmonary; Hypogonadism; Hypopituitarism; Metabolic Syndrome; Ovarian Neoplasms; Peritoneal Neoplasms; Puberty, Precocious; Triple Negative Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Gynecomastia; Breast Neoplasms; Neoplasms

Cytochrome P450 19A1 inhibitor

Small molecule

Approved

OTHER

INTRAMUSCULAR; ORAL

Dyskinesia, Drug-Induced; Lecithin Cholesterol Acyltransferase Deficiency; Mood Disorders; Weight Loss; Amyotrophic Lateral Sclerosis; Anorexia Nervosa; Autistic Disorder; Delirium; Vomiting; Alcoholism; Anxiety; Borderline Personality Disorder; Dementia; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Developmental Disabilities; Feeding and Eating Disorders; Gambling; Genital Neoplasms, Female; Huntington Disease; Intellectual Disability; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Weight Gain; Bipolar Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia

D2-like dopamine receptor antagonist


Small molecule Approved OTHER ORAL Prostatic Neoplasms, Castration-Resistant; Neoplasms; Prostatic Neoplasms Androgen Receptor antagonist

Small molecule

Approved

IMMUNE SYSTEM; OTHER; PEDIATRICS

ORAL

Amyotrophic Lateral Sclerosis; Erectile Dysfunction; Glioblastoma; Hypertension; Hypertension, Pulmonary; Insulin Resistance; Kidney Diseases; Liver Diseases; Malaria; Neoplasm Metastasis; Respiratory Distress Syndrome; Tuberculosis; Coronavirus Infections; Hepatitis B, Chronic; Mycobacterium avium-intracellulare Infection; Neoplasms; Pregnancy; Sarcoma; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Hepatitis D; Infections; Severe Acute Respiratory Syndrome; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Virus Diseases

Cytochrome P450 3A inhibitor

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Postoperative Nausea and Vomiting; Sleep Apnea, Obstructive; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Fibromyalgia; Glioma; Substance-Related Disorders; Weight Loss; Anorexia; Anxiety; Cachexia; Child Development Disorders, Pervasive; Dementia; Heroin Dependence; Nausea; Schizophrenia; Depressive Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders

Adrenergic receptor alpha-2 antagonist