DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 1496


Oligosaccharide Approved CARDIOVASCULAR; OTHER INJECTION Unknown Antithrombin-III activator


Small molecule Approved OTHER TOPICAL Skin Diseases Glucocorticoid receptor agonist


Small molecule Approved OTHER OPHTHALMIC Conjunctivitis, Allergic Histamine H1 receptor antagonist


Small molecule Approved OTHER ORAL Lecithin Cholesterol Acyltransferase Deficiency; Multiple Sclerosis; Alcoholism; Anxiety; Anxiety Disorders; Borderline Personality Disorder; Brain Concussion; Dementia; Depressive Disorder; Neurotic Disorders; Obsessive-Compulsive Disorder; Phobia, Social; Psychomotor Agitation; Psychotic Disorders; Stress Disorders, Post-Traumatic; Bipolar Disorder; Depressive Disorder, Major; Schizophrenia Dopamine D2 receptor antagonist

Small molecule

Approved

OTHER

ORAL

Lecithin Cholesterol Acyltransferase Deficiency; Multiple Sclerosis; Alcoholism; Anxiety; Anxiety Disorders; Borderline Personality Disorder; Brain Concussion; Dementia; Depressive Disorder; Neurotic Disorders; Obsessive-Compulsive Disorder; Phobia, Social; Psychomotor Agitation; Psychotic Disorders; Stress Disorders, Post-Traumatic; Bipolar Disorder; Depressive Disorder, Major; Schizophrenia

Dopamine D2 receptor antagonist


Small molecule Approved OTHER; PHARMACOLOGY INJECTION Macular Degeneration Alcohol dehydrogenase class I inhibitor


Small molecule Approved OTHER ORAL Sarcoma; Diabetes Mellitus Peroxisome proliferator-activated receptor gamma agonist


Small molecule Approved IMMUNE SYSTEM; OTHER; PHARMACOLOGY ORAL Unknown Bacterial DNA gyrase inhibitor


Small molecule Approved OTHER OPHTHALMIC Central Serous Chorioretinopathy; Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension Carbonic anhydrase II inhibitor


Small molecule Approved DERMATOLOGY; OTHER ORAL Amyloidosis; Endometriosis; Epilepsy; Scleroderma, Systemic; Acquired Immunodeficiency Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Appendiceal Neoplasms; Brain Stem Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Castleman Disease; Central Nervous System Neoplasms; Cholangitis, Sclerosing; Colonic Neoplasms; Esophageal Neoplasms; Glioblastoma; Head and Neck Neoplasms; Hepatitis C; Histiocytosis, Langerhans-Cell; HIV Infections; HIV Wasting Syndrome; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Liver Neoplasms; Lupus Erythematosus, Discoid; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Mouth Neoplasms; Neuroblastoma; Neuroendocrine Tumors; Ovarian Neoplasms; Pain; Pancreatitis, Chronic; Paraganglioma; Primary Myelofibrosis; Proctitis; Prostatic Neoplasms; Psoriasis; Purpura, Thrombocytopenic, Idiopathic; Retroviridae Infections; Sarcoma; Severe Acute Respiratory Syndrome; Spondylitis, Ankylosing; Syringomyelia; Thalassemia; Uveal Melanoma; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; beta-Thalassemia; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Colitis, Ulcerative; Colorectal Neoplasms; Cough; Crohn Disease; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hypoalbuminemia; Idiopathic Pulmonary Fibrosis; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Plasma Cell; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoidosis; Stomatitis; Vascular Malformations; Immune System Diseases; Multiple Myeloma CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

DERMATOLOGY; OTHER

ORAL

Amyloidosis; Endometriosis; Epilepsy; Scleroderma, Systemic; Acquired Immunodeficiency Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Appendiceal Neoplasms; Brain Stem Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Castleman Disease; Central Nervous System Neoplasms; Cholangitis, Sclerosing; Colonic Neoplasms; Esophageal Neoplasms; Glioblastoma; Head and Neck Neoplasms; Hepatitis C; Histiocytosis, Langerhans-Cell; HIV Infections; HIV Wasting Syndrome; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Liver Neoplasms; Lupus Erythematosus, Discoid; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Mouth Neoplasms; Neuroblastoma; Neuroendocrine Tumors; Ovarian Neoplasms; Pain; Pancreatitis, Chronic; Paraganglioma; Primary Myelofibrosis; Proctitis; Prostatic Neoplasms; Psoriasis; Purpura, Thrombocytopenic, Idiopathic; Retroviridae Infections; Sarcoma; Severe Acute Respiratory Syndrome; Spondylitis, Ankylosing; Syringomyelia; Thalassemia; Uveal Melanoma; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; beta-Thalassemia; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Colitis, Ulcerative; Colorectal Neoplasms; Cough; Crohn Disease; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hypoalbuminemia; Idiopathic Pulmonary Fibrosis; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Plasma Cell; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoidosis; Stomatitis; Vascular Malformations; Immune System Diseases; Multiple Myeloma

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY INJECTION; INTRAVENOUS; ORAL Breast Neoplasms; Multiple Myeloma; Neoplasms; Neoplasms, Plasma Cell; Pancreatitis, Chronic; Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Hypocalcemia; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Albuminuria; Glomerulonephritis, IGA; Hyperparathyroidism; Hypertrophy, Left Ventricular; Kidney Diseases; Proteinuria; Hyperparathyroidism, Secondary; Parathyroid Diseases; Renal Insufficiency, Chronic Vitamin D receptor agonist

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY

INJECTION; INTRAVENOUS; ORAL

Breast Neoplasms; Multiple Myeloma; Neoplasms; Neoplasms, Plasma Cell; Pancreatitis, Chronic; Carcinoma, Pancreatic Ductal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Hypocalcemia; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Albuminuria; Glomerulonephritis, IGA; Hyperparathyroidism; Hypertrophy, Left Ventricular; Kidney Diseases; Proteinuria; Hyperparathyroidism, Secondary; Parathyroid Diseases; Renal Insufficiency, Chronic

Vitamin D receptor agonist


Antibody Approved OTHER; RESPIRATORY UNKNOWN Hernias, Diaphragmatic, Congenital; Bronchopulmonary Dysplasia; Respiratory Syncytial Virus Infections; Respiratory Tract Diseases Fusion glycoprotein F0 inhibitor


Antibody Approved DIABETES DRUGS & ENDOCRINOLOGY; IMMUNE SYSTEM; OTHER SINGLE-USE DiGeorge Syndrome; Kidney Tubular Necrosis, Acute; Leukemia, Myeloid, Acute; Multiple Myeloma; Neoplasms; Uremia; Amyotrophic Lateral Sclerosis; Colitis, Ulcerative; Glioblastoma; Glomerulosclerosis, Focal Segmental; Granuloma, Lethal Midline; Hodgkin Disease; Kidney Diseases; Renal Insufficiency, Chronic; Uveitis; Diabetes Mellitus, Type 1; Emphysema; Graft vs Host Disease; Infections; Reperfusion Injury; Delayed Graft Function; Immune System Diseases; Kidney Transplantation Interleukin-2 receptor inhibitor

Antibody

Approved

DIABETES DRUGS & ENDOCRINOLOGY; IMMUNE SYSTEM; OTHER

SINGLE-USE

DiGeorge Syndrome; Kidney Tubular Necrosis, Acute; Leukemia, Myeloid, Acute; Multiple Myeloma; Neoplasms; Uremia; Amyotrophic Lateral Sclerosis; Colitis, Ulcerative; Glioblastoma; Glomerulosclerosis, Focal Segmental; Granuloma, Lethal Midline; Hodgkin Disease; Kidney Diseases; Renal Insufficiency, Chronic; Uveitis; Diabetes Mellitus, Type 1; Emphysema; Graft vs Host Disease; Infections; Reperfusion Injury; Delayed Graft Function; Immune System Diseases; Kidney Transplantation

Interleukin-2 receptor inhibitor


Small molecule Approved OTHER; PREGNANCY AND GYNECOLOGY ORAL Prostatic Neoplasms, Castration-Resistant; Sleep Apnea, Obstructive; Alzheimer Disease; HIV Infections; Neuralgia; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Essential Hypertension; Heart Diseases; Kidney Diseases; Kidney Failure, Chronic; Lipid Metabolism Disorders; Polycystic Kidney Diseases; Severe Acute Respiratory Syndrome; Cardiovascular Diseases; Diabetes Mellitus; Hypertension; Myocardial Infarction; Stroke Type-1 angiotensin II receptor antagonist

Small molecule

Approved

OTHER; PREGNANCY AND GYNECOLOGY

ORAL

Prostatic Neoplasms, Castration-Resistant; Sleep Apnea, Obstructive; Alzheimer Disease; HIV Infections; Neuralgia; Albuminuria; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Essential Hypertension; Heart Diseases; Kidney Diseases; Kidney Failure, Chronic; Lipid Metabolism Disorders; Polycystic Kidney Diseases; Severe Acute Respiratory Syndrome; Cardiovascular Diseases; Diabetes Mellitus; Hypertension; Myocardial Infarction; Stroke

Type-1 angiotensin II receptor antagonist


Small molecule Approved OTHER ORAL Cognitive Dysfunction; Hypotension, Orthostatic; Low Back Pain; Melanoma; Psychotic Disorders; Sleep Apnea Syndromes; Sleep Initiation and Maintenance Disorders; Tinnitus; Tobacco Use Disorder; Alcoholism; Amphetamine-Related Disorders; Cognition; Deglutition Disorders; Depressive Disorder; Opioid-Related Disorders; Ovarian Neoplasms; Parkinson Disease; Schizophrenia; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Brain Neoplasms; Cocaine-Related Disorders; Depressive Disorder, Major; Fatigue; Multiple Sclerosis; Postpoliomyelitis Syndrome; Sarcoma, Ewing; Sleep Wake Disorders; Stroke; Attention Deficit Disorder with Hyperactivity; Narcolepsy; Sleep Apnea, Obstructive Dopamine transporter inhibitor

Small molecule

Approved

OTHER

ORAL

Cognitive Dysfunction; Hypotension, Orthostatic; Low Back Pain; Melanoma; Psychotic Disorders; Sleep Apnea Syndromes; Sleep Initiation and Maintenance Disorders; Tinnitus; Tobacco Use Disorder; Alcoholism; Amphetamine-Related Disorders; Cognition; Deglutition Disorders; Depressive Disorder; Opioid-Related Disorders; Ovarian Neoplasms; Parkinson Disease; Schizophrenia; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Brain Neoplasms; Cocaine-Related Disorders; Depressive Disorder, Major; Fatigue; Multiple Sclerosis; Postpoliomyelitis Syndrome; Sarcoma, Ewing; Sleep Wake Disorders; Stroke; Attention Deficit Disorder with Hyperactivity; Narcolepsy; Sleep Apnea, Obstructive

Dopamine transporter inhibitor


Small molecule Approved OTHER ORAL Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Breast Carcinoma In Situ; Carcinoma, Hepatocellular; Depressive Disorder, Major; Fractures, Bone; Hepatolenticular Degeneration; Hypotension, Orthostatic; Inflammation; Keratosis, Actinic; Mouth Neoplasms; Myositis; Neuroblastoma; Obesity; Triple Negative Breast Neoplasms; Tuberculosis; Uterine Cervical Neoplasms; Amyotrophic Lateral Sclerosis; Back Pain; Brain Neoplasms; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cerebral Hemorrhage; Endometrial Neoplasms; Esophageal Neoplasms; Facial Pain; Glioblastoma; Graves Ophthalmopathy; Hepatitis B, Chronic; Lymphangioleiomyomatosis; Medulloblastoma; Melanoma; Multiple Myeloma; Multiple Sclerosis; Muscular Atrophy, Spinal; Neuralgia; Neurofibromatosis 1; Obsessive-Compulsive Disorder; Ovarian Neoplasms; Papilloma; Paraganglioma; Paraproteinemias; Peritoneal Neoplasms; Post-Acute COVID-19 Syndrome; Pre-Eclampsia; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Sarcoma; Schizophrenia; Severe Acute Respiratory Syndrome; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Stomatitis; Temporomandibular Joint Disorders; Tonsillitis; Toothache; Urinary Bladder Neoplasms; Uterine Cervical Dysplasia; Uterine Neoplasms; Adenoma; Alzheimer Disease; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Chronic Pain; Colonic Neoplasms; Colorectal Neoplasms; Depression, Postpartum; Depressive Disorder; Gout; Hand-Foot Syndrome; Head and Neck Neoplasms; Hypertension; Influenza, Human; Liver Neoplasms; Low Back Pain; Lung Neoplasms; Macular Degeneration; Memory Disorders; Nasopharyngeal Carcinoma; Osteoarthritis, Hip; Osteoarthritis, Knee; Pancreatic Neoplasms; Pharyngitis; Rectal Neoplasms; Thyroiditis, Subacute; Tobacco Use Disorder; Wounds and Injuries; Acute Pain; Adenomatous Polyposis Coli; Arthritis, Juvenile; Arthritis, Rheumatoid; Dysmenorrhea; Hemorrhage; Migraine Disorders; Neoplasms; Osteoarthritis; Pain; Peptic Ulcer; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stroke Cyclooxygenase-2 inhibitor

Small molecule

Approved

OTHER

ORAL

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Breast Carcinoma In Situ; Carcinoma, Hepatocellular; Depressive Disorder, Major; Fractures, Bone; Hepatolenticular Degeneration; Hypotension, Orthostatic; Inflammation; Keratosis, Actinic; Mouth Neoplasms; Myositis; Neuroblastoma; Obesity; Triple Negative Breast Neoplasms; Tuberculosis; Uterine Cervical Neoplasms; Amyotrophic Lateral Sclerosis; Back Pain; Brain Neoplasms; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cerebral Hemorrhage; Endometrial Neoplasms; Esophageal Neoplasms; Facial Pain; Glioblastoma; Graves Ophthalmopathy; Hepatitis B, Chronic; Lymphangioleiomyomatosis; Medulloblastoma; Melanoma; Multiple Myeloma; Multiple Sclerosis; Muscular Atrophy, Spinal; Neuralgia; Neurofibromatosis 1; Obsessive-Compulsive Disorder; Ovarian Neoplasms; Papilloma; Paraganglioma; Paraproteinemias; Peritoneal Neoplasms; Post-Acute COVID-19 Syndrome; Pre-Eclampsia; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rotator Cuff Injuries; Sarcoma; Schizophrenia; Severe Acute Respiratory Syndrome; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Stomatitis; Temporomandibular Joint Disorders; Tonsillitis; Toothache; Urinary Bladder Neoplasms; Uterine Cervical Dysplasia; Uterine Neoplasms; Adenoma; Alzheimer Disease; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Chronic Pain; Colonic Neoplasms; Colorectal Neoplasms; Depression, Postpartum; Depressive Disorder; Gout; Hand-Foot Syndrome; Head and Neck Neoplasms; Hypertension; Influenza, Human; Liver Neoplasms; Low Back Pain; Lung Neoplasms; Macular Degeneration; Memory Disorders; Nasopharyngeal Carcinoma; Osteoarthritis, Hip; Osteoarthritis, Knee; Pancreatic Neoplasms; Pharyngitis; Rectal Neoplasms; Thyroiditis, Subacute; Tobacco Use Disorder; Wounds and Injuries; Acute Pain; Adenomatous Polyposis Coli; Arthritis, Juvenile; Arthritis, Rheumatoid; Dysmenorrhea; Hemorrhage; Migraine Disorders; Neoplasms; Osteoarthritis; Pain; Peptic Ulcer; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stroke

Cyclooxygenase-2 inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY ORAL Breast Diseases; Breast Neoplasms; Bronchiolitis Obliterans Syndrome; Hemosiderosis; HIV Infections; Melanoma; Neoplasms; IgA Vasculitis; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Multiple Myeloma; Pemphigoid, Bullous; Prostatic Neoplasms, Castration-Resistant; Sjogren's Syndrome; Smoldering Multiple Myeloma; Uveitis; Central Nervous System Neoplasms; Lupus Nephritis; Myasthenia Gravis; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Arthritis, Psoriatic; Arthritis, Rheumatoid Dihydroorotate dehydrogenase inhibitor

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY

ORAL

Breast Diseases; Breast Neoplasms; Bronchiolitis Obliterans Syndrome; Hemosiderosis; HIV Infections; Melanoma; Neoplasms; IgA Vasculitis; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Multiple Myeloma; Pemphigoid, Bullous; Prostatic Neoplasms, Castration-Resistant; Sjogren's Syndrome; Smoldering Multiple Myeloma; Uveitis; Central Nervous System Neoplasms; Lupus Nephritis; Myasthenia Gravis; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Arthritis, Psoriatic; Arthritis, Rheumatoid

Dihydroorotate dehydrogenase inhibitor


Enzyme Approved OTHER ORAL Unknown Sucrose hydrolytic enzyme


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Amyloid Neuropathies, Familial; Cocaine-Related Disorders; Executive Function; Neuroblastoma; Alcoholism; Brain Injuries; Gambling; Obsessive-Compulsive Disorder; Pick Disease of the Brain; Schizophrenia; Tobacco Use Disorder; Liver Failure; Parkinson Disease Catechol O-methyltransferase inhibitor


Protein Approved OTHER; RHEUMATOLOGY SUBCUTANEOUS; UNKNOWN Fanconi Anemia; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic Syndromes; Myositis, Inclusion Body; Neoplasms; Persian Gulf Syndrome; Prostatic Neoplasms, Castration-Resistant; Sciatica; Subarachnoid Hemorrhage; Acquired Hyperostosis Syndrome; Alzheimer Disease; Asthma; Chronic Urticaria; Dermatomyositis; Graft vs Host Disease; Granulomatosis with Polyangiitis; Hidradenitis Suppurativa; Histiocytosis; Immunoglobulin Light-chain Amyloidosis; Leukemia; Lichen Planus; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Pemphigus; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Radiculopathy; Renal Insufficiency, Chronic; Reperfusion Injury; Sjogren's Syndrome; Stomatitis; Synovitis; Temporomandibular Joint Disorders; Tinnitus; Vitiligo; Anorexia; Arthritis; Cachexia; Diabetes Mellitus, Type 1; Inflammation; Pneumonia; Polymyalgia Rheumatica; Stevens-Johnson Syndrome; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Immune System Diseases; Psoriasis; Spondylarthropathies; Spondylitis; Spondylitis, Ankylosing TNF-alpha inhibitor

Protein

Approved

OTHER; RHEUMATOLOGY

SUBCUTANEOUS; UNKNOWN

Fanconi Anemia; HIV Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic Syndromes; Myositis, Inclusion Body; Neoplasms; Persian Gulf Syndrome; Prostatic Neoplasms, Castration-Resistant; Sciatica; Subarachnoid Hemorrhage; Acquired Hyperostosis Syndrome; Alzheimer Disease; Asthma; Chronic Urticaria; Dermatomyositis; Graft vs Host Disease; Granulomatosis with Polyangiitis; Hidradenitis Suppurativa; Histiocytosis; Immunoglobulin Light-chain Amyloidosis; Leukemia; Lichen Planus; Lupus Erythematosus, Cutaneous; Lupus Nephritis; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Pemphigus; Pulmonary Disease, Chronic Obstructive; Pulmonary Fibrosis; Radiculopathy; Renal Insufficiency, Chronic; Reperfusion Injury; Sjogren's Syndrome; Stomatitis; Synovitis; Temporomandibular Joint Disorders; Tinnitus; Vitiligo; Anorexia; Arthritis; Cachexia; Diabetes Mellitus, Type 1; Inflammation; Pneumonia; Polymyalgia Rheumatica; Stevens-Johnson Syndrome; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Immune System Diseases; Psoriasis; Spondylarthropathies; Spondylitis; Spondylitis, Ankylosing

TNF-alpha inhibitor


Small molecule Approved CANCER; OTHER ORAL Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paraganglioma; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pseudomyxoma Peritonei; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms; Stomach Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

ORAL

Carcinoma, Merkel Cell; Central Nervous System Neoplasms; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Urinary Bladder Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Fallopian Tube Neoplasms; Glioblastoma; Glioma; Head and Neck Neoplasms; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Lung Neoplasms; Mesothelioma; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paraganglioma; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pseudomyxoma Peritonei; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Thyroid Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Brain Diseases; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Esophageal Neoplasms; Gallbladder Neoplasms; Hand-Foot Syndrome; Liver Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neuroendocrine Tumors; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Neoplasms; Stomach Neoplasms

DNA inhibitor


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cardiovascular Diseases; Brain Injuries; Pain; Severe Acute Respiratory Syndrome; Atherosclerosis; Breast Neoplasms; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Renovascular; Proteinuria; Renal Artery Obstruction; Angina Pectoris; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke Type-1 angiotensin II receptor antagonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cardiovascular Diseases; Brain Injuries; Pain; Severe Acute Respiratory Syndrome; Atherosclerosis; Breast Neoplasms; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Renovascular; Proteinuria; Renal Artery Obstruction; Angina Pectoris; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke

Type-1 angiotensin II receptor antagonist


Unknown Approved OTHER INTRATRACHEAL Acute Lung Injury; Bronchopulmonary Dysplasia; Respiratory Distress Syndrome; Respiratory Distress Syndrome, Newborn Surfactant agent


Small molecule Approved OTHER ORAL Unknown Unknown


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Diabetes Mellitus, Type 2; Hepatitis C; Lymphoma, Non-Hodgkin; Malaria; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Acquired Immunodeficiency Syndrome; Tuberculosis; Autoimmune Diseases; HIV Infections; Infections; Virus Diseases Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

ORAL

Diabetes Mellitus, Type 2; Hepatitis C; Lymphoma, Non-Hodgkin; Malaria; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Acquired Immunodeficiency Syndrome; Tuberculosis; Autoimmune Diseases; HIV Infections; Infections; Virus Diseases

Human immunodeficiency virus type 1 reverse transcriptase inhibitor


Small molecule Approved OTHER INTRAVESICAL Carcinoma in Situ; Urinary Bladder Neoplasms; Carcinoma; Neoplasms DNA inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL HIV Infections; Central Nervous System Neoplasms; Head and Neck Neoplasms; Heart Failure; Leukoplakia, Oral; Non-alcoholic Fatty Liver Disease; Pituitary ACTH Hypersecretion; Sarcoma; Atherosclerosis; Insulin Resistance; Diabetes Mellitus; Diabetes Mellitus, Type 2 Peroxisome proliferator-activated receptor gamma agonist

Small molecule

Approved

OTHER

ORAL; TOPICAL

Carcinoma, Intraductal, Noninfiltrating; Multiple Myeloma; Pituitary ACTH Hypersecretion; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Alopecia Areata; Alzheimer Disease; Breast Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Myelodysplastic Syndromes; Parapsoriasis; Psoriasis; Sezary Syndrome; Carcinoma, Non-Small-Cell Lung; Cognitive Dysfunction; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Mycosis Fungoides; Psychotic Disorders; Schizophrenia; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Neoplasms

Retinoid X receptor agonist

Protein

Approved

OTHER

UNKNOWN

Breast Neoplasms, Male; Carcinoma, Endometrioid; Cystadenoma, Serous; Kidney Neoplasms; Multiple Myeloma; Fallopian Tube Neoplasms; Graft vs Host Disease; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Melanoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Lymphoma; Lymphoma, T-Cell, Peripheral; Lymphoma, T-Cell, Cutaneous; Neoplasms

Elongation factor 2 inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Virus Diseases; Influenza, Human; Kidney Failure, Chronic Neuraminidase inhibitor


Small molecule Approved OTHER ORAL Metabolic Syndrome; Hyperlipoproteinemia Type I; Polycystic Ovary Syndrome; Infertility; Obesity Gastric lipase inhibitor


Small molecule Approved MUSCULOSKELETAL; OTHER; RHEUMATOLOGY ORAL Brain Neoplasms; Paraganglioma; Alzheimer Disease; Carcinoma, Non-Small-Cell Lung; Adenoma; Colorectal Neoplasms; Joint Diseases; Osteoarthritis; Osteoarthritis, Knee; Pain; Prostatic Neoplasms, Castration-Resistant; Stomach Neoplasms; Rheumatic Diseases Cyclooxygenase-2 inhibitor

Small molecule

Approved

OTHER

ORAL

CADASIL; Fatty Liver; Osteoarthritis; Pain; Cerebral Small Vessel Diseases; Cognitive Dysfunction; Heart Failure; Intermittent Claudication; Stroke; Urticaria; Wounds and Injuries; Arthritis, Rheumatoid; Atherosclerosis; Cardiovascular Diseases; Cerebral Infarction; Cerebrovascular Disorders; Coronary Disease; Ischemic Stroke; Peripheral Arterial Disease; Peripheral Vascular Diseases; Thrombosis

Phosphodiesterase 3A inhibitor

Small molecule

Approved

CANCER; OTHER

INTRAVENOUS; ORAL

Cytomegalovirus Infections; Desmoplastic Small Round Cell Tumor; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Wilms Tumor; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Myelodysplastic Syndromes; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pheochromocytoma; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Uveal Melanoma; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Ganglioneuroblastoma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroblastoma; Oligodendroglioma; Optic Nerve Glioma; Paraganglioma; Sarcoma, Ewing; Glioblastoma; Glioma; Neoplasms

DNA inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

INTRAVENOUS; ORAL

Aphasia; Canavan Disease; Essential Tremor; Lymphoma, Follicular; Stroke; Alzheimer Disease; Anemia, Sickle Cell; Bipolar Disorder; Brain Neoplasms; Cocaine-Related Disorders; Cognitive Dysfunction; Dyskinesia, Drug-Induced; Epilepsy, Absence; Epilepsy, Reflex; Glioblastoma; Leukemia, Myeloid, Acute; Neuralgia, Postherpetic; Neuroblastoma; Obsessive-Compulsive Disorder; Opioid-Related Disorders; Paraganglioma; Parkinson Disease; Polyneuropathies; Psychotic Disorders; Restless Legs Syndrome; Stress Disorders, Post-Traumatic; Torticollis; Alcoholism; Anxiety; Dementia; Depressive Disorder; Epilepsies, Partial; Movement Disorders; Panic Disorder; Schizophrenia; Status Epilepticus; Subarachnoid Hemorrhage; Substance Withdrawal Syndrome; Epilepsy; Epilepsy, Tonic-Clonic; Seizures

Synaptic vesicle glycoprotein 2A modulator


Small molecule Approved EYE; OTHER OPHTHALMIC Chronic Pain; Conjunctivitis, Allergic; Dermatitis; Fractures, Bone; Rhinitis, Allergic, Perennial Histamine H1 receptor antagonist