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Total: 1496
Small molecule
Approved
OTHER
OPHTHALMIC
Conjunctivitis, Allergic; Eye Manifestations
Histamine H1 receptor antagonist
Small molecule
Approved
OTHER
TOPICAL
Lice Infestations
Nicotinic acetylcholine receptor agonist
Antibody
Approved
CANCER; OTHER
INJECTION
Hematologic Neoplasms; HIV Infections; Leukemia; Leukemia, Myeloid, Acute; Enteropathy-Associated T-Cell Lymphoma; Graft vs Host Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Mast-Cell; Lupus Erythematosus, Systemic; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mastocytosis, Systemic; Mesothelioma, Malignant; Neoplasms, Germ Cell and Embryonal; Scleroderma, Diffuse; Sezary Syndrome; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Cutaneous; Mycosis Fungoides; Hodgkin Disease; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms
Tubulin inhibitor
Small molecule
Approved
OTHER; UROLOGY AND KIDNEY
ORAL
Kidney Diseases; Erectile Dysfunction
Phosphodiesterase 5A inhibitor
Small molecule
Approved
OTHER
INHALATION
Asthma; Lung Diseases; Bronchitis, Chronic; Emphysema; Pulmonary Disease, Chronic Obstructive
Beta-2 adrenergic receptor agonist
Small molecule
Approved
OTHER
INTRAVENOUS
Arthritis, Rheumatoid; Cystitis, Interstitial; Genital Neoplasms, Female; Heart Failure; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Neoplasms; Central Nervous System Diseases
Diagnostic agent
Small molecule
Approved
CARDIOVASCULAR; HEMATOLOGY; OTHER
ORAL
Blood Coagulation Disorders; Obesity, Morbid; Renal Insufficiency, Chronic; Anemia, Sickle Cell; Aortic Valve Disease; Heart Diseases; Hemorrhage; Ischemia; Multiple Myeloma; Thromboembolism; Angina, Unstable; Aortic Valve Stenosis; Diabetes Mellitus, Type 2; Hematoma; Hip Fractures; Ischemic Stroke; Liver Cirrhosis; Myocardial Infarction; Neoplasms; Polyendocrinopathies, Autoimmune; Renal Insufficiency; Rheumatic Heart Disease; Severe Acute Respiratory Syndrome; Thrombocytopenia; Acute Coronary Syndrome; Arthroplasty, Replacement; Atrial Fibrillation; Coronary Artery Disease; Peripheral Arterial Disease; Pulmonary Embolism; Stroke; Thrombosis; Venous Thromboembolism; Venous Thrombosis
Coagulation factor X inhibitor
Small molecule
Approved
CANCER; OTHER; RESPIRATORY
ORAL
Breast Neoplasms; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Glioblastoma; Kidney Diseases; Prostatic Neoplasms, Castration-Resistant; Adenocarcinoma; Bile Duct Neoplasms; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Endometrial Neoplasms; Gallbladder Neoplasms; Granuloma, Plasma Cell; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Multiple Myeloma; Neurofibromatosis 2; Stomach Neoplasms; Uveal Melanoma; Adenocarcinoma of Lung; Carcinoma; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
ALK tyrosine kinase receptor inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Polycystic Ovary Syndrome; Renal Insufficiency; Breast Neoplasms; Diabetes Mellitus, Type 1; Obesity; Renal Insufficiency, Chronic; Diabetic Nephropathies; Heart Failure; Diabetes Mellitus; Diabetes Mellitus, Type 2
Sodium/glucose cotransporter 2 inhibitor
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Amyotrophic Lateral Sclerosis; Depressive Disorder; Depressive Disorder, Major; Neuralgia, Postherpetic; Epilepsy; Seizures
KCNQ (Kv7) potassium channel opener
Small molecule
Approved
CARDIOVASCULAR; OTHER
ORAL
Hypertension; Stroke
Type-1 angiotensin II receptor antagonist
Small molecule
Approved
OTHER
ORAL
Hepatitis C; Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Small molecule
Approved
OTHER
ORAL
Adenocarcinoma; Carcinoma; Central Nervous System Neoplasms; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Glioma; Neuroblastoma; Paraganglioma; Pheochromocytoma; Rectal Neoplasms; Adenocarcinoma, Follicular; Astrocytoma; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Head and Neck Neoplasms; Kidney Neoplasms; Leukemia, Myeloid, Acute; Mesothelioma; Multiple Myeloma; Neoplasm Metastasis; Oligodendroglioma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Stomach Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Carcinoma, Medullary; Neoplasms; Thyroid Neoplasms
Ephrin receptor inhibitor
Small molecule
Approved
DERMATOLOGY; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Kidney Diseases; Alcoholism; Diabetic Neuropathies; Migraine Disorders; Neuralgia, Postherpetic; Restless Legs Syndrome
Voltage-gated calcium channel modulator
Small molecule
Approved
GASTROINTESTINAL; OTHER; UROLOGY AND KIDNEY
ORAL
Bone Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Rhabdomyosarcoma; Small Cell Lung Carcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Renal Cell; Cholangiocarcinoma; Digestive System Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Hemangiosarcoma; Liposarcoma; Macular Degeneration; Melanoma; Meningioma; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Colorectal Neoplasms; Neoplasms
Discoidin domain-containing receptor 2 inhibitor
Small molecule
Approved
OTHER
ORAL
Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 integrase inhibitor
Small molecule
Approved
OTHER
INTRAVENOUS
Prostatic Neoplasms
Diagnostic agent
Small molecule
Approved
MUSCULOSKELETAL; OTHER
ORAL
Celiac Disease; Kidney Diseases; Paraparesis, Tropical Spastic; Purpura, Thrombocytopenic, Idiopathic; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting
Dihydroorotate dehydrogenase inhibitor
Protein
Approved
GASTROINTESTINAL; OTHER
ORAL
Adenoma; Colorectal Neoplasms; Constipation; Irritable Bowel Syndrome
Heat-stable enterotoxin receptor agonist
Small molecule
Approved
OTHER; UROLOGY AND KIDNEY
ORAL
Esophageal Achalasia; Kidney Diseases; Liver Diseases; Polycystic Ovary Syndrome; Cerebral Hemorrhage; Heart Failure; Hypertrophy, Left Ventricular; Pain; Prediabetic State; Urinary Bladder, Neurogenic; Cystitis, Interstitial; Kidney Calculi; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge
Beta-3 adrenergic receptor agonist
Small molecule
Approved
OTHER
ORAL
Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Insulin Resistance; Leukemia, Biphenotypic, Acute; Malaria; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Neoplasms; Acquired Immunodeficiency Syndrome; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; HIV Infections; Infections
Cytochrome P450 3A inhibitor
Small molecule
Approved
CANCER; OTHER; UROLOGY AND KIDNEY
ORAL
Blast Crisis; Breast Neoplasms; Carcinoma; Endometriosis; Gliosarcoma; Mesothelioma; Neoplasm Metastasis; Stomach Neoplasms; Adrenal Cortex Neoplasms; Biliary Tract Neoplasms; Carcinoid Tumor; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Gastrointestinal Stromal Tumors; Glioblastoma; Leukemia, Myeloid, Acute; Liver Neoplasms; Lung Neoplasms; Melanoma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Paraganglioma; Pheochromocytoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Sarcoma, Alveolar Soft Part; Skin Neoplasms; Solitary Fibrous Tumors; Thyroid Neoplasms; Carcinoma, Pancreatic Ductal; Kidney Neoplasms; Carcinoma, Renal Cell; Neoplasms
Vascular endothelial growth factor receptor inhibitor
Antibody
Approved
OTHER
IV (INFUSION)
Anthrax
Protective antigen binding agent
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
ORAL
Alcoholism; Bipolar Disorder; Depressive Disorder, Major; Torticollis; Amyotrophic Lateral Sclerosis; Diabetic Neuropathies; Essential Tremor; Migraine Disorders; Neuralgia; Small Fiber Neuropathy; Epilepsy, Tonic-Clonic; Lennox Gastaut Syndrome; Parkinson Disease; Epilepsies, Partial; Epilepsy; Seizures
Glutamate receptor ionotropic AMPA antagonist
Small molecule
Approved
CANCER; HEMATOLOGY; OTHER
ORAL
Anemia, Sickle Cell; Burkitt Lymphoma; Castleman Disease; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Pancreatic Neoplasms; Small Cell Lung Carcinoma; Waldenstrom Macroglobulinemia; Amyloidosis; Amyloidosis, Familial; Central Nervous System Neoplasms; Graft vs Host Disease; Leukemia, Plasma Cell; Lung Diseases, Interstitial; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Myeloproliferative Disorders; Neoplasms, Plasma Cell; Plasmacytoma; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Pulmonary Fibrosis; Sarcoma; Sarcoma, Kaposi; Scleroderma, Systemic; Smoldering Multiple Myeloma; Telangiectasia, Hereditary Hemorrhagic; Primary Myelofibrosis; Immune System Diseases; Multiple Myeloma
CRL4(CRBN) E3 ubiquitin ligase inhibitor
Unknown
Approved
OTHER
ORAL
Unknown
Unknown
Small molecule
Approved
CANCER; OTHER
ORAL
Multiple Myeloma; Carcinoma, Non-Small-Cell Lung
Epidermal growth factor receptor erbB1 inhibitor
Small molecule
Approved
OTHER
INTRAVENOUS
Lung Diseases, Interstitial; Brain Neoplasms; Central Nervous System Diseases
Diagnostic agent
Small molecule
Approved
OTHER
ORAL
Depressive Disorder, Major
Norepinephrine transporter inhibitor
Small molecule
Approved
OTHER
ORAL
Hepatitis B, Chronic; Lymphoma; Infections; Severe Acute Respiratory Syndrome; Hepatitis C; Hepatitis C, Chronic; Virus Diseases
RNA-directed RNA polymerase inhibitor
Small molecule
Approved
IMMUNE SYSTEM; MUSCULOSKELETAL; OTHER
ORAL
Gliosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cerebral Hemorrhage; Ischemic Stroke; Lymphoma, T-Cell, Cutaneous; Sleep Apnea, Obstructive; Multiple Sclerosis, Chronic Progressive; Severe Acute Respiratory Syndrome; Immune System Diseases; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Psoriasis
Kelch-like ECH-associated protein 1 inhibitor
Small molecule
Approved
CARDIOVASCULAR; OTHER; RESPIRATORY
ORAL
HIV Infections; Anemia, Sickle Cell; Coronary Disease; Cystic Fibrosis; Ischemic Stroke; Raynaud Disease; Scleroderma, Localized; Scleroderma, Systemic; Ulcer; Familial Primary Pulmonary Hypertension; Hypertension; Hypertension, Pulmonary
Soluble guanylate cyclase positive allosteric modulator
Protein
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
INJECTION
Diabetes Mellitus, Type 1; Polydipsia; Renal Insufficiency, Chronic; Smoking Cessation; Diabetes Mellitus; Diabetes Mellitus, Type 2
Glucagon-like peptide 1 receptor agonist
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Sleep Apnea Syndromes; Tobacco Use Disorder; Alcoholism; Alzheimer Disease; Autistic Disorder; Opioid-Related Disorders; Restless Legs Syndrome; Sleep Wake Disorders; Smoking Cessation; Delirium; Sleep Initiation and Maintenance Disorders
Orexin receptor antagonist
Small molecule
Approved
OTHER
INTRAVENOUS
Influenza, Human
Neuraminidase inhibitor