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Total: 10647
Small molecule
Unknown
Unknown
Unknown
Esophagitis, Peptic; Laryngopharyngeal Reflux; Cerebrovascular Disorders; Duodenal Ulcer; Gastroesophageal Reflux; Zollinger-Ellison Syndrome
Potassium-transporting ATPase inhibitor
Small molecule
Approved
Unknown
Unknown
Osteomyelitis
Bacterial 70S ribosome inhibitor
Small molecule
Approved
IMMUNE SYSTEM; OTHER
ORAL
Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 protease inhibitor
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Amphetamine-Related Disorders; Gastrointestinal Stromal Tumors; Epilepsy; Obesity; Cocaine-Related Disorders; Parkinson Disease
Catechol O-methyltransferase inhibitor
Small molecule
Approved
Unknown
Unknown
Anemia; Breast Neoplasms; Erectile Dysfunction; Glomerulosclerosis, Focal Segmental; Malaria; Malaria, Falciparum; Nausea; Neoplasms; Arthritis, Rheumatoid; Asthma; Cognitive Dysfunction; Colitis, Ulcerative; Endometriosis; HIV Infections; Insulin Resistance; Mycosis Fungoides; Non-alcoholic Fatty Liver Disease; Prediabetic State; Sezary Syndrome; Alzheimer Disease; Atherosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Glucose Intolerance; Hypercholesterolemia; Hypertension; Lipid Metabolism Disorders; Metabolic Diseases; Metabolic Syndrome; Multiple Organ Failure; Prostatic Neoplasms; Diabetes Mellitus
Unknown
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
HIV Infections; Central Nervous System Neoplasms; Head and Neck Neoplasms; Heart Failure; Leukoplakia, Oral; Non-alcoholic Fatty Liver Disease; Pituitary ACTH Hypersecretion; Sarcoma; Atherosclerosis; Insulin Resistance; Diabetes Mellitus; Diabetes Mellitus, Type 2
Peroxisome proliferator-activated receptor gamma agonist
Small molecule
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Brain Neoplasms; Glioma; Alzheimer Disease; Carcinoma, Non-Small-Cell Lung; Adenoma; Colorectal Neoplasms; Joint Diseases; Osteoarthritis; Osteoarthritis, Knee; Pain; Prostatic Neoplasms, Castration-Resistant; Stomach Neoplasms; Rheumatic Diseases
Cyclooxygenase-2 inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY
INJECTION; ORAL
Neoplasms; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Hyperparathyroidism, Secondary; Parathyroid Diseases; Renal Insufficiency, Chronic
Vitamin D receptor agonist
Small molecule
Approved
OTHER
ORAL; TOPICAL
Thyroid Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Multiple Myeloma; Pituitary ACTH Hypersecretion; Alopecia Areata; Alzheimer Disease; Breast Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Myelodysplastic Syndromes; Parapsoriasis; Psoriasis; Sezary Syndrome; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Mycosis Fungoides; Psychotic Disorders; Schizophrenia; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Neoplasms
Retinoid X receptor agonist
Small molecule
Approved
EYE; OTHER
OPHTHALMIC
Osteomyelitis; Cataract; Tuberculosis; Bacterial Infections; Conjunctivitis, Bacterial; Eye Infections; Infections
DNA gyrase inhibitor
Small molecule
Approved
Unknown
Unknown
Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Hodgkin Disease; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Testicular Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Inflammatory Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Nasopharyngeal Neoplasms; Stomach Neoplasms; Thrombosis; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Gastroparesis; Inflammation; Peripheral Arterial Disease; Anemia; Astrocytoma; Brain Neoplasms; Crohn Disease; Cystic Fibrosis; Diabetes Mellitus, Type 1; Glioblastoma; Granulomatous Disease, Chronic; Lupus Erythematosus, Systemic; Melanoma; Meningioma; Multiple Myeloma; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Neoplasms; Prostatic Neoplasms; Pulmonary Alveolar Proteinosis; Adrenoleukodystrophy; Alcoholism; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Asthma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiovascular Diseases; Cerebral Hemorrhage; Child Development Disorders, Pervasive; Cognitive Dysfunction; Depressive Disorder, Major; Glucose Intolerance; Hepatitis; Hepatitis C; Hepatitis C, Chronic; Hypertension, Pulmonary; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Liposarcoma; Liposarcoma, Myxoid; Lung Neoplasms; Non-alcoholic Fatty Liver Disease; Obesity; Opioid-Related Disorders; Pancreatic Neoplasms; Parkinson Disease; Polycystic Kidney Diseases; Polycystic Ovary Syndrome; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Renal Insufficiency, Chronic; Stroke; Thyroid Neoplasms; Arthritis, Rheumatoid; Atherosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Fatty Liver; Friedreich Ataxia; HIV-Associated Lipodystrophy Syndrome; Hypercholesterolemia; Hypertension; Liver Diseases; Metabolic Syndrome; Diabetes Mellitus
Unknown
Protein
Approved
Unknown
Unknown
Diabetes Mellitus; Diabetes Mellitus, Type 2
Insulin receptor agonist
Small molecule
Approved
HEMATOLOGY
ORAL
Cognitive Dysfunction; HIV Infections; Amyotrophic Lateral Sclerosis; beta-Thalassemia; Dementia; Friedreich Ataxia; Parkinson Disease; Acute Kidney Injury; Hemochromatosis; Pantothenate Kinase-Associated Neurodegeneration; Anemia, Sickle Cell; Thalassemia
Unknown
Small molecule
Unknown
Unknown
Unknown
Pain; Pregnancy
Sodium channel protein type IV alpha subunit blocker
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Carcinoma, Intraductal, Noninfiltrating; Tobacco Use Disorder; Anxiety; Breast Neoplasms, Male; Diabetes Mellitus; Persian Gulf Syndrome; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Adenomyosis; Alcoholism; Alzheimer Disease; Bipolar Disorder; Borderline Personality Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Serous Chorioretinopathy; Cocaine-Related Disorders; Endometrial Neoplasms; Endometriosis; Fallopian Tube Neoplasms; Hepatitis C; HIV Infections; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Stress Disorders, Post-Traumatic; Abortion, Spontaneous; Depressive Disorder; Depressive Disorder, Major; Leiomyoma; Meningioma; Pituitary ACTH Hypersecretion; Cushing Syndrome
Glucocorticoid receptor antagonist
Small molecule
Approved
HEMATOLOGY; OTHER; UROLOGY AND KIDNEY
INTRAVENOUS
Renal Insufficiency; Hematologic Neoplasms; Hypertension, Pulmonary; Anemia; Anemia, Iron-Deficiency; Renal Insufficiency, Chronic
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Oligosaccharide
Unknown
Unknown
Unknown
Kidney Neoplasms; Ischemic Stroke; Multiple Myeloma; Pneumonia; Thromboembolism; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Severe Acute Respiratory Syndrome; Thrombosis; Venous Thrombosis
Antithrombin-III activator
Protein
Unknown
Unknown
Unknown
Polycystic Ovary Syndrome; Ovarian Hyperstimulation Syndrome; Hypogonadism; Infertility; Obesity; Primary Ovarian Insufficiency
Luteinizing hormone/Choriogonadotropin receptor agonist
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Cocaine-Related Disorders; Hearing Loss, Noise-Induced; Tobacco Use Disorder; Essential Tremor; Hearing Loss; Migraine Disorders; Obesity; Parkinson Disease; Alcoholism; Epilepsy, Complex Partial; Feeding and Eating Disorders; Psychotic Disorders; Schizophrenia; Smoking Cessation; Weight Gain; Epilepsy; Seizures
Sodium channel alpha subunit blocker
Small molecule
Unknown
Unknown
Unknown
Acquired Immunodeficiency Syndrome; Brain Neoplasms; Carcinoma, Basal Cell; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Colorectal Neoplasms; Gliosarcoma; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Melanoma; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Breast Neoplasms; Carcinoma, Hepatocellular; Endometrial Neoplasms; Graft vs Host Disease; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Lung Neoplasms; Lupus Erythematosus, Systemic; Lymphoma; Multiple Myeloma; Neuroblastoma; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Leukemia, Promyelocytic, Acute; Neoplasms
Thioredoxin reductase 1 inhibitor
Antibody
Approved
CANCER
INJECTION; SINGLE-DOSE
Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelomonocytic, Juvenile; Leukemia, Promyelocytic, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Leukemia, Myeloid; Neoplasms
DNA inhibitor
Small molecule
Approved
Unknown
TOPICAL
Nausea; Communicable Diseases; Acromegaly; Anemia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Burns; Colitis, Ulcerative; Constipation; Eczema; Infections; Multiple Sclerosis; Prostatic Neoplasms; Psoriasis; Spondylitis, Ankylosing
Unknown
Small molecule
Approved
MUSCULOSKELETAL; OTHER
ORAL
Lupus Erythematosus, Systemic; Dysmenorrhea; Pharyngitis; Toothache; Low Back Pain; Migraine Disorders; Pain; Prostatic Neoplasms; Shoulder Pain; Spondylitis, Ankylosing; Tuberculosis; Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases
Cyclooxygenase-2 inhibitor
Protein
Approved
OTHER; PREGNANCY AND GYNECOLOGY
INJECTION
Arthritis, Rheumatoid; Endometriosis; Infertility; Ovarian Hyperstimulation Syndrome; Prostatic Hyperplasia
Unknown
Small molecule
Approved
OTHER
ORAL
Diabetes Mellitus; Diabetes Mellitus, Type 2
Sulfonylurea receptor 1, Kir6.2 blocker
Small molecule
Approved
Unknown
Unknown
Renal Insufficiency; Pain; Periodontitis; Pulpitis
Unknown
Small molecule
Approved
IMMUNE SYSTEM
TOPICAL
Herpes Simplex; Virus Diseases
Envelope glycoprotein inhibitor
Protein
Approved
CARDIOVASCULAR; OTHER
INJECTION; INTRAVENOUS
Venous Thrombosis; Acute Coronary Syndrome; Acute Disease; Aortic Valve Stenosis; Cardiovascular Diseases; Coronary Disease; Heart Diseases; Hematologic Diseases; Hemorrhage; Myocardial Infarction; Subarachnoid Hemorrhage; Angina, Unstable; Syndrome; Thrombocytopenia; Thrombosis
Thrombin inhibitor
Protein
Unknown
Unknown
Unknown
HIV Infections; Lymphoma; Salivary Gland Neoplasms; Breast Neoplasms; Endometriosis; Infertility; Ovarian Hyperstimulation Syndrome; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Puberty, Precocious; Neoplasms
Unknown
Small molecule
Approved
OTHER
INTRAVENOUS; ORAL
Burns; Cystic Fibrosis; Meningitis; Abscess; Cellulitis; Gram-Positive Bacterial Infections; Optic Nerve Diseases; Pneumonia, Bacterial; Pneumonia, Pneumococcal; Skin Diseases; Staphylococcal Infections; Tuberculosis; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Bacteremia; Bacterial Infections; Infections; Osteomyelitis; Pneumonia
Bacterial 70S ribosome inhibitor
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Pregnancy; Diabetes Mellitus; Bipolar Disorder; Graves Disease; Hypothyroidism; Congenital Hypothyroidism; Lipid Metabolism Disorders
Unknown
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
TRANSDERMAL
Amphetamine-Related Disorders; Cocaine-Related Disorders; Down Syndrome; Substance-Related Disorders; Anxiety; Brain Injuries; Cognitive Dysfunction; Delirium; Dementia, Vascular; Depressive Disorder; Neurobehavioral Manifestations; Schizophrenia; Supranuclear Palsy, Progressive; Alzheimer Disease; Dementia; Parkinson Disease
Cholinesterases; ACHE & BCHE inhibitor