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Total: 10647
Small molecule
Approved
CARDIOVASCULAR; OTHER; RESPIRATORY
INHALATION; INTRAVENOUS; IV (INFUSION); SUBCUTANEOUS
Raynaud Disease; Diabetic Foot; Reperfusion Injury; Scleroderma, Systemic; Hernias, Diaphragmatic, Congenital; Ischemia; Peripheral Vascular Diseases; Persistent Fetal Circulation Syndrome; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Familial Primary Pulmonary Hypertension; Idiopathic Pulmonary Fibrosis; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis
Prostanoid IP receptor agonist
Small molecule
Approved
OTHER
ORAL
Prostatic Neoplasms, Castration-Resistant; HIV Infections; Hepatitis C, Chronic; Hepatitis D; Non-alcoholic Fatty Liver Disease; Aortic Valve Stenosis; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Metabolic Syndrome; Metabolism, Inborn Errors; Myocardial Infarction; Cardiovascular Diseases; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II
Niemann-Pick C1-like protein 1 inhibitor
Small molecule
Approved
IMMUNE SYSTEM; OTHER
INJECTION; INTRAVENOUS; IV (INFUSION); ORAL
Asthma; Graft vs Host Disease; Hematologic Neoplasms; HIV Infections; Keratitis; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms; Neutropenia; Aspergillosis, Allergic Bronchopulmonary; Myelodysplastic Syndromes; Candidiasis, Invasive; Leukemia; Leukemia, Myeloid, Acute; Mycoses; Neuroaspergillosis; Aspergillosis; Candidemia; Candidiasis; Fusariosis; Infections
Cytochrome P450 51 inhibitor
Protein
Approved
GASTROINTESTINAL; OTHER
INTRAVENOUS
Autistic Disorder
Secretin receptor agonist
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Protein
Approved
IMMUNE SYSTEM; OTHER
SUBCUTANEOUS; UNKNOWN
Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Clostridium Infections; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Multiple Myeloma; Thrombocytopenia; Depressive Disorder; Hepatitis; Hepatitis C; Hepatitis D; HIV Infections; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Cirrhosis; Melanoma; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Hepatitis B; Hepatitis B, Chronic; Hepatitis C, Chronic
Interferon alpha/beta receptor agonist
Protein
Approved
GASTROINTESTINAL; OTHER
INJECTION
Dyspepsia; Pancreatitis, Chronic; Obesity; Pancreatitis; Schizophrenia; Autistic Disorder
Secretin receptor agonist
Antibody
Approved
CANCER
INJECTION
Burkitt Lymphoma; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Waldenstrom Macroglobulinemia; Graft vs Host Disease; Leukemia; Lymphoma; Lymphoma, Mantle-Cell; Multiple Myeloma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin
B-lymphocyte antigen CD20 binding agent
Unknown
Approved
OTHER
INTRAPERITONEAL
Renal Insufficiency, Chronic; Heart Failure
Osmotic agent
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
Constipation; Irritable Bowel Syndrome
Serotonin 4 (5-HT4) receptor partial agonist
Small molecule
Unknown
Unknown
Unknown
Glomerulonephritis; Atherosclerosis; Diabetic Nephropathies; Essential Hypertension; Kidney Diseases; Proteinuria; Cardiovascular Diseases; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke
Type-1 angiotensin II receptor antagonist
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Enzyme
Approved
CANCER
INTRAVENOUS
Burkitt Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Hyperuricemia; Tumor Lysis Syndrome; Gout; Leukemia; Lymphoma
Uric acid oxidative enzyme
Small molecule
Approved
OTHER
ORAL
Common Cold; Infections; Respiratory Tract Infections; Cough; Fever; Headache; Sinusitis
Unknown
Small molecule
Approved
Unknown
Unknown
Alzheimer Disease; Hepatitis C; Aphasia; Borderline Personality Disorder; Cocaine-Related Disorders; Digestive System Diseases; Fibromyalgia; Panic Disorder; Phobia, Social; Phobic Disorders; Renal Insufficiency, Chronic; Stress Disorders, Post-Traumatic; Stroke; Substance-Related Disorders; Anxiety; Anxiety Disorders; Bipolar Disorder; Carcinoma; Dementia; Depressive Disorder, Major; Hypertension, Pulmonary; Neoplasms; Obsessive-Compulsive Disorder; Schizophrenia; Depressive Disorder
Unknown
Small molecule
Approved
Unknown
Unknown
Dyspepsia; Gastroesophageal Reflux; Constipation
Unknown
Antibody
Unknown
Unknown
Unknown
Mucopolysaccharidoses; Thyroid Neoplasms; Asthma; Colitis; Dupuytren Contracture; Glomerulosclerosis, Focal Segmental; Inflammation; Netherton Syndrome; Osteoarthritis, Knee; Sarcoidosis; Sciatica; Wet Macular Degeneration; Arthritis, Juvenile; Behcet Syndrome; Crohn Disease; Cystitis, Interstitial; Giant Cell Arteritis; Hidradenitis Suppurativa; Inflammatory Bowel Diseases; Osteoarthritis; Pyoderma; Severe Acute Respiratory Syndrome; Uveitis; Arthritis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Immune System Diseases; Psoriasis; Spondylitis, Ankylosing
TNF-alpha inhibitor
Small molecule
Approved
CANCER
INTRAMUSCULAR
Carcinoma, Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Lymphoma; Lymphoma, Non-Hodgkin; Mesothelioma; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Fibrous Dysplasia, Polyostotic; Genital Neoplasms, Female; Hypertension, Pulmonary; Lung Neoplasms; Lupus Erythematosus, Systemic; Ovarian Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Endometrial Stromal; Uterine Neoplasms; Carcinoma, Lobular; Neoplasm Metastasis; Breast Neoplasms; Neoplasms
Estrogen receptor antagonist
Small molecule
Approved
OTHER
INTRAMUSCULAR; ORAL; ORALLY DISINTEGRATING
Amphetamine-Related Disorders; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Fragile X Syndrome; Obsessive-Compulsive Disorder; Alcoholism; Alzheimer Disease; Anorexia Nervosa; Anxiety; Child Development Disorders, Pervasive; Dementia; Depression, Postpartum; Stress Disorders, Post-Traumatic; Tourette Syndrome; Aggression; Autistic Disorder; Bipolar Disorder; Depressive Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia
Dopamine D2 receptor partial agonist
Small molecule
Approved
CARDIOVASCULAR; OTHER
ORAL
Diabetes Mellitus, Type 2; Atrial Fibrillation; Breast Neoplasms; Central Serous Chorioretinopathy; Diabetic Nephropathies; Hyperparathyroidism, Primary; Cardiomyopathies; Essential Hypertension; Muscular Dystrophy, Duchenne; Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Stroke
Mineralocorticoid receptor antagonist
Small molecule
Approved
Unknown
Unknown
Constipation; Multiple Sclerosis; Kidney Calculi; Prostatitis; Urinary Bladder, Neurogenic; Urinary Retention; Prostatic Hyperplasia
Unknown
Small molecule
Approved
Unknown
Unknown
Friedreich Ataxia; Anemia; Angioedemas, Hereditary; Asthma; Carcinoma, Non-Small-Cell Lung; Craniocerebral Trauma; Crohn Disease; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Immune System Diseases; Lupus Erythematosus, Systemic; Malaria; Melanoma; Metabolic Diseases; Neoplasms; Non-alcoholic Fatty Liver Disease; Parkinson Disease; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Respiratory Syncytial Virus Infections; Skin Diseases; Amnesia; Arthritis, Rheumatoid; Breast Neoplasms; Burns; Cerebral Hemorrhage; Colitis, Ulcerative; Depressive Disorder; Diabetes Mellitus; Diabetic Neuropathies; Endometrial Hyperplasia; Endometrial Neoplasms; Hepatitis C; Ischemia; Myocardial Infarction; Orthomyxoviridae Infections; Ovarian Neoplasms; Periodontitis; Pre-Eclampsia; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Renal Artery Obstruction; Sepsis; Tuberculosis, Pulmonary; Venous Thromboembolism; Acute Coronary Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Aortic Valve Stenosis; Atherosclerosis; Cardiomyopathy, Dilated; Colorectal Neoplasms; Coronary Artery Disease; Coronary Disease; Heart Failure; Hip Fractures; HIV Infections; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hypertension; Lipid Metabolism Disorders; Metabolic Syndrome; Necrosis; Obesity; Renal Insufficiency; Scleroderma, Systemic; Severe Acute Respiratory Syndrome; Stroke; Cardiovascular Diseases
Unknown
Small molecule
Approved
Unknown
Unknown
Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Eye Manifestations; Hypersensitivity
Unknown
Small molecule
Approved
Unknown
Unknown
Dermatitis, Atopic
Unknown
Antibody
Approved
Unknown
Unknown
Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma; Lymphoma, Non-Hodgkin
B-lymphocyte antigen CD20 binding agent
Small molecule
Approved
Unknown
Unknown
Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Unknown
Small molecule
Approved
CANCER
ORAL
Carcinoma, Renal Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
Epidermal growth factor receptor erbB1 inhibitor
Small molecule
Unknown
Unknown
Unknown
Gastroesophageal Reflux
Potassium-transporting ATPase inhibitor
Protein
Approved
CANCER
INTRAMUSCULAR
Prostatic Neoplasms, Castration-Resistant; Neoplasms
Gonadotropin-releasing hormone receptor antagonist
Small molecule
Approved
Unknown
ORAL
Diabetes Mellitus, Type 1; Hematologic Neoplasms; Severe Acute Respiratory Syndrome; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Unknown
Enzyme
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY
INTRAVENOUS
Fabry Disease
Globotriosylceramide hydrolytic enzyme
Small molecule
Approved
Unknown
Unknown
Unknown
Radioactive metals chelating agent
Small molecule
Approved
OTHER
ORAL
Hepatitis C; Insulin Resistance; Tuberculosis; Liver Cirrhosis, Biliary; Acquired Immunodeficiency Syndrome; Hepatitis B, Chronic; Infections; Severe Acute Respiratory Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Protein
Approved
DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER
SUBCUTANEOUS
Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Prostatic Neoplasms; Sarcoma; Fibrous Dysplasia, Polyostotic; Pituitary Diseases; Acromegaly
Growth hormone receptor antagonist
Antibody
Approved
RESPIRATORY
UNKNOWN
Colonic Neoplasms; Dermatitis, Atopic; Drug Hypersensitivity; Job Syndrome; Lupus Erythematosus, Systemic; Bronchitis; Eosinophilic Esophagitis; Food Hypersensitivity; Gastroenteritis; Hypersensitivity; Immune System Diseases; Milk Hypersensitivity; Nephritis, Interstitial; Pemphigoid, Bullous; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sinusitis; Angioedema; Cystitis, Interstitial; Peanut Hypersensitivity; Rhinitis, Allergic, Seasonal; Asthma; Lung Diseases, Obstructive; Urticaria
Ig epsilon chain C region inhibitor